NLM DIR Seminar Schedule
UPCOMING SEMINARS
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May 29, 2025 Harutyun Sahakyan
In silico evolution of globular protein folds from random sequences -
June 3, 2025 MG Hirsch
TBD -
June 10, 2025 Aleksandra Foerster
TBD -
June 17, 2025 Yoshitaka Inoue
TBD -
June 19, 2025 Ermin Hodzic
TBD
RECENT SEMINARS
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May 20, 2025 Ajith Pankajam
A roadmap from single cell to knowledge graph -
May 2, 2025 Pascal Mutz
Characterization of covalently closed cirular RNAs detected in (meta)transcriptomic data -
May 2, 2025 Dr. Lang Wu
Integration of multi-omics data in epidemiologic research -
April 22, 2025 Stanley Liang, PhD
Large Vision Model for medical knowledge adaptation -
April 18, 2025 Valentina Boeva, Department of Computer Science, ETH Zurich
Decoding tumor heterogeneity: computational methods for scRNA-seq and spatial omics
Scheduled Seminars on Nov. 28, 2023
Contact NLMDIRSeminarScheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi.