NLM IRP Seminar Schedule
UPCOMING SEMINARS
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May 21, 2024 Ziynet Kesimoglu
Multiomics Data Integration using Graph Convolutional Networks -
May 23, 2024 Leslie Ronish
Identification of fold-switching proteins by FLIM-FRET -
May 28, 2024 Harutyun Saakyan
TBD -
May 30, 2024 Deepak Gupta
TBD
RECENT SEMINARS
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May 14, 2024 Stanley Liang
Knowledge-driven Latent Diffusion For COVID-19 Pneumonia Radiology Pattern Synthesis -
May 9, 2024 Pascal Mutz
The Riboviria protein structurome expands virus protein annotation and highlights protein relations -
April 30, 2024 Wenya Rowe
The conformal central charge of the spin-1/2 XX model derived from long-chain asymptotics -
April 25, 2024 Ermin Hodzic
Condition-Aware Cell Type Deconvolution of Bulk Tissues -
April 16, 2024 Jaya Srivastava
Regulatory plasticity of the human genome
Scheduled Seminars on Dec. 8, 2022
Contact NLM_IRP_Seminar_Scheduling@mail.nih.gov with questions about this seminar.
Abstract:
Using a custom computational pipeline, we searched 5,131 global metatranscriptomes for viroid-like circular RNAs. By combining direct sequence searches against ViroidDB, a comprehensive collection of viroids and viroid-like sequences, with structure-based searches for self-cleaving ribozymes, we were able to identify 4,860 novel viroid-like sequence clusters containing a range of ribozymes. Clustering these sequences reveals a fivefold increase in diversity relative to known viroid-like agents. The novel sequences span the viroid-like space from putative viroids to ribozyviruses and retrozymes. Additionally, we identify the ribozy-like nature of certain riboviruses infecting fungi and provide evidence for CRISPR targeting of viroid-like RNAs.