NLM IRP Seminar Schedule
UPCOMING SEMINARS
-
May 21, 2024 Ziynet Kesimoglu
Multiomics Data Integration using Graph Convolutional Networks -
May 23, 2024 Leslie Ronish
Identification of fold-switching proteins by FLIM-FRET -
May 28, 2024 Harutyun Saakyan
TBD -
May 30, 2024 Deepak Gupta
TBD
RECENT SEMINARS
-
May 21, 2024 Ziynet Kesimoglu
Multiomics Data Integration using Graph Convolutional Networks -
May 14, 2024 Stanley Liang
Knowledge-driven Latent Diffusion For COVID-19 Pneumonia Radiology Pattern Synthesis -
May 9, 2024 Pascal Mutz
The Riboviria protein structurome expands virus protein annotation and highlights protein relations -
April 30, 2024 Wenya Rowe
The conformal central charge of the spin-1/2 XX model derived from long-chain asymptotics -
April 25, 2024 Ermin Hodzic
Condition-Aware Cell Type Deconvolution of Bulk Tissues
Scheduled Seminars on Oct. 19, 2023
Contact NLM_IRP_Seminar_Scheduling@mail.nih.gov with questions about this seminar.
Abstract:
While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-selfish element immunity, recent findings have revealed immune effectors that target their building blocks and the cellular energy currency – free nucleotides. Through comparative genomics and sequence-structure analysis, we identified several distinct effector domains, which we named Calcineurin-CE, HD-CE, and PRTase-CE. These domains, along with specific versions of the ParB and MazG domains, are widely present in diverse prokaryotic immune systems and are predicted to degrade nucleotides by targeting phosphate or glycosidic linkages. Our findings unveil multiple potential immune systems associated with at least 17 different functional themes featuring these effectors. Some of these systems sense modified DNA/nucleotides from phages or operate downstream of novel enzymes generating signaling nucleotides. We also uncovered a class of systems utilizing HSP90- and HSP70-related modules as analogs of STAND and GTPase domains that are coupled to these nucleotide-targeting- or proteolysis-induced complex-forming effectors. While widespread in bacteria, only a limited subset of nucleotide-targeting effectors was integrated into eukaryotic immune systems, suggesting barriers to interoperability across subcellular contexts. This work establishes nucleotide-degrading effectors as an emerging immune paradigm and traces their origins back to homologous domains in housekeeping systems.